Dataset Open Access

Data publication: Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Clauß, Oliver; Schäker-Hübner, Linda; Wenzel, Barbara; Toussaint, Magali; Deuther-Conrad, Winnie; Gündel, Daniel; Teodoro, Rodrigo; Dukic-Stefanovic, Sladjana; Ludwig, Friedrich-Alexander; Kopka, Klaus; Brust, Peter; Hansen, Finn K.; Scheunemann, Matthias


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    <dct:title>Data publication: Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain</dct:title>
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    <dcat:keyword>histone deacetylase inhibitor</dcat:keyword>
    <dcat:keyword>HDAC1/2-specific</dcat:keyword>
    <dcat:keyword>radiochemistry</dcat:keyword>
    <dcat:keyword>fluorine-18 labelling</dcat:keyword>
    <dcat:keyword>positron emission tomography (PET)</dcat:keyword>
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    <dcat:keyword>glioblastoma</dcat:keyword>
    <dcat:keyword>glioma</dcat:keyword>
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    <dct:description>&lt;p&gt;The data publication contain: 1) Radiosynthesis data (Scheme of the synthesis module; RP-HPLC chromatograms of formulated [18F]BA3; MLC chromatograms of in vivo metabolism studies) 2) Biological data (Baseline TAC of CD-1 mice brain, biodistribution after i.v. injection of [18F]BA3) 3) Analytical data (1H, 13C, 19F NMR spectra; LC-MS chromatograms for final products)&lt;/p&gt;</dct:description>
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