Dataset Open Access

Data publication: Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension

Arndt, Philipp; Morton, Lorena; Briese, Michael; Lämmlin, Naomi; Mattern, Hendrik; Hasanuzzaman, Md.; Westhues, Melina; Khoshneviszadeh, Mahsima; Appenzeller, Silke; Gündel, Daniel; Toussaint, Magali; Brust, Peter; Knieß, Torsten; Oelschlegel, Anja; Goldschmidt, Jürgen; Meuth, Sven; Müller, Patrick; Braun‐Dullaeus, Rüdiger; Debska‐Vielhaber, Grazyna; Vielhaber, Stefan; Becker, Axel; Dityatev, Alexander; Henneicke, Solveig; Sendtner, Michael; Dunay, Ildiko; Schreiber, Stefanie

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      <creatorName>Arndt, Philipp</creatorName>
      <givenName>Philipp</givenName>
      <familyName>Arndt</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
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      <creatorName>Morton, Lorena</creatorName>
      <givenName>Lorena</givenName>
      <familyName>Morton</familyName>
      <affiliation>Institute of Inflammation and Neurodegeneration, Otto-­von-­Guericke University, Magdeburg</affiliation>
    </creator>
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      <creatorName>Briese, Michael</creatorName>
      <givenName>Michael</givenName>
      <familyName>Briese</familyName>
      <affiliation>Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg</affiliation>
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      <creatorName>Lämmlin, Naomi</creatorName>
      <givenName>Naomi</givenName>
      <familyName>Lämmlin</familyName>
      <affiliation>Department of Neurology, University Hospital Leipzig, Leipzig</affiliation>
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      <creatorName>Mattern, Hendrik</creatorName>
      <givenName>Hendrik</givenName>
      <familyName>Mattern</familyName>
      <affiliation>German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Magdeburg</affiliation>
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    <creator>
      <creatorName>Hasanuzzaman, Md.</creatorName>
      <givenName>Md.</givenName>
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      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
    </creator>
    <creator>
      <creatorName>Westhues, Melina</creatorName>
      <givenName>Melina</givenName>
      <familyName>Westhues</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
    </creator>
    <creator>
      <creatorName>Khoshneviszadeh, Mahsima</creatorName>
      <givenName>Mahsima</givenName>
      <familyName>Khoshneviszadeh</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
    </creator>
    <creator>
      <creatorName>Appenzeller, Silke</creatorName>
      <givenName>Silke</givenName>
      <familyName>Appenzeller</familyName>
      <affiliation>Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg</affiliation>
    </creator>
    <creator>
      <creatorName>Gündel, Daniel</creatorName>
      <givenName>Daniel</givenName>
      <familyName>Gündel</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-9743-2325</nameIdentifier>
    </creator>
    <creator>
      <creatorName>Toussaint, Magali</creatorName>
      <givenName>Magali</givenName>
      <familyName>Toussaint</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-1136-3857</nameIdentifier>
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    <creator>
      <creatorName>Brust, Peter</creatorName>
      <givenName>Peter</givenName>
      <familyName>Brust</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-5555-7058</nameIdentifier>
    </creator>
    <creator>
      <creatorName>Knieß, Torsten</creatorName>
      <givenName>Torsten</givenName>
      <familyName>Knieß</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-4107-3455</nameIdentifier>
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    <creator>
      <creatorName>Oelschlegel, Anja</creatorName>
      <givenName>Anja</givenName>
      <familyName>Oelschlegel</familyName>
      <affiliation>Leibniz-­Institute for Neurobiology, Magdeburg</affiliation>
    </creator>
    <creator>
      <creatorName>Goldschmidt, Jürgen</creatorName>
      <givenName>Jürgen</givenName>
      <familyName>Goldschmidt</familyName>
      <affiliation>Leibniz-­Institute for Neurobiology, Magdeburg</affiliation>
    </creator>
    <creator>
      <creatorName>Meuth, Sven</creatorName>
      <givenName>Sven</givenName>
      <familyName>Meuth</familyName>
      <affiliation>Department of Neurology, Heinrich-­Heine-­University, Düsseldorf</affiliation>
    </creator>
    <creator>
      <creatorName>Müller, Patrick</creatorName>
      <givenName>Patrick</givenName>
      <familyName>Müller</familyName>
      <affiliation>Department of Cardiology, Otto-­von-­Guericke University, Magdeburg</affiliation>
    </creator>
    <creator>
      <creatorName>Braun‐Dullaeus, Rüdiger</creatorName>
      <givenName>Rüdiger</givenName>
      <familyName>Braun‐Dullaeus</familyName>
      <affiliation>Department of Cardiology, Otto-­von-­Guericke University, Magdeburg</affiliation>
    </creator>
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      <creatorName>Debska‐Vielhaber, Grazyna</creatorName>
      <givenName>Grazyna</givenName>
      <familyName>Debska‐Vielhaber</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
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    <creator>
      <creatorName>Vielhaber, Stefan</creatorName>
      <givenName>Stefan</givenName>
      <familyName>Vielhaber</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
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    <creator>
      <creatorName>Becker, Axel</creatorName>
      <givenName>Axel</givenName>
      <familyName>Becker</familyName>
      <affiliation>Institute of Pharmacology and Toxicology, Otto-­von-­Guericke University, Magdeburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Dityatev, Alexander</creatorName>
      <givenName>Alexander</givenName>
      <familyName>Dityatev</familyName>
      <affiliation>German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Magdeburg</affiliation>
    </creator>
    <creator>
      <creatorName>Henneicke, Solveig</creatorName>
      <givenName>Solveig</givenName>
      <familyName>Henneicke</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
    </creator>
    <creator>
      <creatorName>Sendtner, Michael</creatorName>
      <givenName>Michael</givenName>
      <familyName>Sendtner</familyName>
      <affiliation>Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg</affiliation>
    </creator>
    <creator>
      <creatorName>Dunay, Ildiko</creatorName>
      <givenName>Ildiko</givenName>
      <familyName>Dunay</familyName>
      <affiliation>Institute of Inflammation and Neurodegeneration, Otto-­von-­Guericke University, Magdeburg</affiliation>
    </creator>
    <creator>
      <creatorName>Schreiber, Stefanie</creatorName>
      <givenName>Stefanie</givenName>
      <familyName>Schreiber</familyName>
      <affiliation>Department of Neurology, Otto-­von-­Guericke 2. Palta P, Albert MS, Gottesman RF. Heart health meets cognitive health: evidence on the role of blood pressure. Lancet Neurol. 2021;20:854– 867. doi: 10.1016/S1474-­4422(21)00248-­9 3. Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M. Vascular cognitive impairment and dementia. J Am Coll Cardiol. 2019;73:3326–3344. doi: 10.1016/j.jacc.2019.04.034 4. Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan L-­J. Cerebral sm</affiliation>
    </creator>
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  <titles>
    <title>Data publication: Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension</title>
  </titles>
  <publisher>Rodare</publisher>
  <publicationYear>2025</publicationYear>
  <subjects>
    <subject>18F-­FDG PET</subject>
    <subject>cerebral small-­vessel disease</subject>
    <subject>hypertension</subject>
    <subject>RNA sequencing</subject>
    <subject>SHRSP</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2025-12-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Dataset"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://rodare.hzdr.de/record/4168</alternateIdentifier>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsReferencedBy">10.1161/JAHA.125.040710</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsIdenticalTo">https://www.hzdr.de/publications/Publ-42332</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsReferencedBy">https://www.hzdr.de/publications/Publ-42331</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;datasheet animals (rats) for FDG-PET and DICOMS of PET aquisitions&lt;/p&gt;</description>
  </descriptions>
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Publication date:
December 1, 2025
DOI:
10.14278/rodare.4168

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10.14278/rodare.4168

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Keyword(s):
18F-­FDG PET cerebral small-­vessel disease hypertension RNA sequencing SHRSP
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https://www.hzdr.de/publications/Publ-42332
Referenced by:
10.1161/JAHA.125.040710, https://www.hzdr.de/publications/Publ-42331
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