Dataset Open Access
Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.
Müller, Johannes;
Suckert, Theresa;
Beyreuther, Elke;
Schneider, Moritz;
Boucsein, Marc;
Bodenstein, Elisabeth;
Stolz-Kieslich, Liane;
Krause, Mechthild;
von Neubeck, Cläre;
Haase, Robert;
Lühr, Armin;
Dietrich, Antje
JSON-LD (schema.org) Export
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"description": "<p>The dataset contains comprehensive image data for a total of nine mice, which underwent normal tissue brain irradiation with 90 MeV protons. <br>\nIn particular, the image data comprise cone-bem computed tomographies (CBCT), Monte Carlo beam transport simulations based on those CTs, regular magnetic resonance imaging (MRI) follow-up (≥ 26 weeks), a co-aligned DSURQE mouse brain atlas and scanned whole-brain tissue sections with histochemical and immunofluorescent markers for morphology (H&E), cell nuclei (DAPI), astrocytes (GFAP), microglia (Iba1), the intermediate filament protein Nestin, proliferation (Ki67), neurons (NeuN) and oligodendrocytes (OSP). <br>\nThe volumetric image data (i.e. CBCT, MRI and brain atlas) were co-aligned using the ImageJ plugin Big Warp. The CBCT data was used as spatial reference to allow for mask-based, slice-wise alignment of CBCT and light microscopy image data in 3D with the scriptable registration tool Elastix. </p>\n\n<p>We provide the data in raw format and as aligned data sets, as well as their spatial transformations.</p>",
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"affiliation": "OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01309, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology - OncoRay, Dresden, 01309, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany;"
},
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"affiliation": "OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01309, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"
},
{
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"@type": "Person",
"name": "Haase, Robert",
"affiliation": "DFG Cluster of Excellence Physics of Life, TU Dresden"
},
{
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"@type": "Person",
"name": "L\u00fchr, Armin",
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},
{
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"name": "Dietrich, Antje",
"affiliation": "OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01309, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany;"
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],
"version": "0.3.1"
}
8,602
54,010
views
downloads
| All versions | This version | |
|---|---|---|
| Views | 8,602 | 2,158 |
| Downloads | 54,010 | 17,081 |
| Data volume | 664.4 TB | 216.7 TB |
| Unique views | 4,997 | 1,602 |
| Unique downloads | 24,029 | 10,291 |
- Publication date:
- January 20, 2021
- DOI:
-
- Keyword(s):
- Preclinical Image fusion Proton radiation Medical imaging Histology
- Grants:
-
European Commission:
- INSPIRE - INfraStructure in Proton International REsearch (730983)
- Related identifiers:
- Identical to:
https://www.hzdr.de/publications/Publ-32124 - Referenced by:
https://www.hzdr.de/publications/Publ-31469 - Communities:
- License (for files):
- Creative Commons Attribution 4.0 International