Dataset Open Access
Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.
Müller, Johannes;
Suckert, Theresa;
Beyreuther, Elke;
Schneider, Moritz;
Boucsein, Marc;
Bodenstein, Elisabeth;
Stolz-Kieslich, Liane;
Krause, Mechthild;
von Neubeck, Cläre;
Haase, Robert;
Lühr, Armin;
Dietrich, Antje
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"affiliation": "OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01309, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology - OncoRay, Dresden, 01309, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; TU Dortmund, Dortmund, Germany",
"name": "L\u00fchr, Armin",
"@type": "Person",
"@id": "https://orcid.org/0000-0002-9450-6859"
},
{
"affiliation": "OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01309, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany;",
"name": "Dietrich, Antje",
"@type": "Person",
"@id": "https://orcid.org/0000-0002-9783-1104"
}
],
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"description": "<p>The dataset contains comprehensive image data for a total of nine mice, which underwent normal tissue brain irradiation with 90 MeV protons. <br>\nIn particular, the image data comprise cone-bem computed tomographies (CBCT), Monte Carlo beam transport simulations based on those CTs, regular magnetic resonance imaging (MRI) follow-up (≥ 26 weeks), a co-aligned DSURQE mouse brain atlas and scanned whole-brain tissue sections with histochemical and immunofluorescent markers for morphology (H&E), cell nuclei (DAPI), astrocytes (GFAP), microglia (Iba1), the intermediate filament protein Nestin, proliferation (Ki67), neurons (NeuN) and oligodendrocytes (OSP). <br>\nThe volumetric image data (i.e. CBCT, MRI and brain atlas) were co-aligned using the ImageJ plugin Big Warp. The CBCT data was used as spatial reference to allow for mask-based, slice-wise alignment of CBCT and light microscopy image data in 3D with the scriptable registration tool Elastix. </p>\n\n<p>We provide the data in raw format and as aligned data sets, as well as their spatial transformations.</p>",
"identifier": "https://doi.org/10.14278/rodare.915",
"sameAs": [
"https://www.hzdr.de/publications/Publ-32124"
],
"name": "Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.",
"keywords": [
"Preclinical",
"Image fusion",
"Proton radiation",
"Medical imaging",
"Histology"
],
"@id": "https://doi.org/10.14278/rodare.915",
"version": "0.3.1",
"datePublished": "2021-01-20"
}
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|---|---|---|
| Views | 11,698 | 2,574 |
| Downloads | 95,527 | 24,180 |
| Data volume | 1.2 PB | 321.8 TB |
| Unique views | 6,961 | 1,947 |
| Unique downloads | 51,553 | 16,157 |
- Publication date:
- January 20, 2021
- DOI:
-
- Keyword(s):
- Preclinical Image fusion Proton radiation Medical imaging Histology
- Grants:
-
European Commission:
- INSPIRE - INfraStructure in Proton International REsearch (730983)
- Related identifiers:
- Identical to:
https://www.hzdr.de/publications/Publ-32124 - Referenced by:
https://www.hzdr.de/publications/Publ-31469 - Communities:
- License (for files):
- Creative Commons Attribution 4.0 International