Dataset Open Access
Müller, Johannes; Suckert, Theresa; Beyreuther, Elke; Schneider, Moritz; Boucsein, Marc; Bodenstein, Elisabeth; Stolz-Kieslich, Liane; Krause, Mechthild; von Neubeck, Cläre; Haase, Robert; Lühr, Armin; Dietrich, Antje
{ "abstract": "<p>The dataset contains comprehensive image data for a total of nine mice, which underwent normal tissue brain irradiation with 90 MeV protons. <br>\nIn particular, the image data comprise cone-bem computed tomographies (CBCT), Monte Carlo beam transport simulations based on those CTs, regular magnetic resonance imaging (MRI) follow-up (≥ 26 weeks), a co-aligned DSURQE mouse brain atlas and scanned whole-brain tissue sections with histochemical and immunofluorescent markers for morphology (H&E), cell nuclei (DAPI), astrocytes (GFAP), microglia (Iba1), the intermediate filament protein Nestin, proliferation (Ki67), neurons (NeuN) and oligodendrocytes (OSP). <br>\nThe volumetric image data (i.e. CBCT, MRI and brain atlas) were co-aligned using the ImageJ plugin Big Warp. The CBCT data was used as spatial reference to allow for mask-based, slice-wise alignment of CBCT and light microscopy image data in 3D with the scriptable registration tool Elastix. </p>\n\n<p>We provide the data in raw format and as aligned data sets, as well as their spatial transformations.</p>", "title": "Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.", "issued": { "date-parts": [ [ 2021, 1, 20 ] ] }, "author": [ { "family": "M\u00fcller, Johannes" }, { "family": "Suckert, Theresa" }, { "family": "Beyreuther, Elke" }, { "family": "Schneider, Moritz" }, { "family": "Boucsein, Marc" }, { "family": "Bodenstein, Elisabeth" }, { "family": "Stolz-Kieslich, Liane" }, { "family": "Krause, Mechthild" }, { "family": "von Neubeck, Cl\u00e4re" }, { "family": "Haase, Robert" }, { "family": "L\u00fchr, Armin" }, { "family": "Dietrich, Antje" } ], "DOI": "10.14278/rodare.810", "publisher": "Rodare", "language": "eng", "id": "810", "type": "dataset", "version": "0.3" }
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