March 10, 2022 Dataset Open Access

Clauß, Oliver; Schäker-Hübner, Linda; Wenzel, Barbara; Toussaint, Magali; Deuther-Conrad, Winnie; Gündel, Daniel; Teodoro, Rodrigo; Dukic-Stefanovic, Sladjana; Ludwig, Friedrich-Alexander; Kopka, Klaus; Brust, Peter; Hansen, Finn K.; Scheunemann, Matthias

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{
  "@id": "https://doi.org/10.14278/rodare.1475", 
  "sameAs": [
    "https://www.hzdr.de/publications/Publ-34366"
  ], 
  "identifier": "https://doi.org/10.14278/rodare.1475", 
  "creator": [
    {
      "@id": "https://orcid.org/0000-0001-5067-4845", 
      "@type": "Person", 
      "name": "Clau\u00df, Oliver"
    }, 
    {
      "affiliation": "Universit\u00e4t Bonn", 
      "@type": "Person", 
      "name": "Sch\u00e4ker-H\u00fcbner, Linda"
    }, 
    {
      "@id": "https://orcid.org/0000-0001-7390-3575", 
      "@type": "Person", 
      "name": "Wenzel, Barbara"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-1136-3857", 
      "@type": "Person", 
      "name": "Toussaint, Magali"
    }, 
    {
      "@id": "https://orcid.org/0000-0003-3168-3062", 
      "@type": "Person", 
      "name": "Deuther-Conrad, Winnie"
    }, 
    {
      "@id": "https://orcid.org/0000-0001-9743-2325", 
      "@type": "Person", 
      "name": "G\u00fcndel, Daniel"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-1425-0567", 
      "@type": "Person", 
      "name": "Teodoro, Rodrigo"
    }, 
    {
      "@type": "Person", 
      "name": "Dukic-Stefanovic, Sladjana"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-4358-5171", 
      "@type": "Person", 
      "name": "Ludwig, Friedrich-Alexander"
    }, 
    {
      "@id": "https://orcid.org/0000-0003-4846-1271", 
      "@type": "Person", 
      "name": "Kopka, Klaus"
    }, 
    {
      "@id": "https://orcid.org/0000-0001-5555-7058", 
      "@type": "Person", 
      "name": "Brust, Peter"
    }, 
    {
      "affiliation": "Universit\u00e4t Bonn", 
      "@id": "https://orcid.org/0000-0001-9765-5975", 
      "@type": "Person", 
      "name": "Hansen, Finn K."
    }, 
    {
      "@type": "Person", 
      "name": "Scheunemann, Matthias"
    }
  ], 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "name": "Data publication: Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [\u00b9\u2078F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain", 
  "keywords": [
    "histone deacetylase inhibitor", 
    "HDAC1/2-specific", 
    "radiochemistry", 
    "fluorine-18 labelling", 
    "positron emission tomography (PET)", 
    "brain-penetration", 
    "glioblastoma", 
    "glioma"
  ], 
  "distribution": [
    {
      "fileFormat": "pdf", 
      "@type": "DataDownload", 
      "contentUrl": "https://rodare.hzdr.de/api/files/d38202d4-baba-4a0d-a992-95cd2ba58e6c/Clau\u00df_Scheunemann_Development_Biological_Evaluation_Benzamide-Based_Radiotracer_HDAC1_2_Brain_Pharmaceuticals_2022_15_324_SI.pdf"
    }
  ], 
  "description": "<p>The data publication contain: 1) Radiosynthesis data (Scheme of the synthesis module; RP-HPLC chromatograms of formulated [18F]BA3; MLC chromatograms of in vivo metabolism studies) 2) Biological data (Baseline TAC of CD-1 mice brain, biodistribution after i.v. injection of [18F]BA3) 3) Analytical data (1H, 13C, 19F NMR spectra; LC-MS chromatograms for final products)</p>", 
  "@context": "https://schema.org/", 
  "datePublished": "2022-03-10", 
  "@type": "Dataset", 
  "url": "https://rodare.hzdr.de/record/1475"
}