November 11, 2021 Dataset Open Access

Moldovan, Rares-Petru

MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nmm##2200000uu#4500</leader>
  <controlfield tag="005">20211215143124.0</controlfield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">109662</subfield>
    <subfield code="u">https://rodare.hzdr.de/record/1261/files/18FLU14_FP_Spyke_Grad10_90_10_20AA_ReprosilAq_RC1_21_01_201.TXT</subfield>
    <subfield code="z">md5:296e50c29d7c21419520f59b9a18c7bc</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">110258</subfield>
    <subfield code="u">https://rodare.hzdr.de/record/1261/files/18FLU14_Metab_Brain_Mouse3_MeOH_spyked_Grad10_90_10_ReprosilAq_RC1_27_02_201.TXT</subfield>
    <subfield code="z">md5:8c42c62f65f5460dd299c744166bf73f</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">110991</subfield>
    <subfield code="u">https://rodare.hzdr.de/record/1261/files/18FLU14_Metab_Plasma_Mouse3_MeOH_spyked_Grad10_90_10_ReprosilAq_RC1_27_02_201.TXT</subfield>
    <subfield code="z">md5:a3eb6189d7e0b8d8636e4e79eb56e78f</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">111271</subfield>
    <subfield code="u">https://rodare.hzdr.de/record/1261/files/18FLU14_Mouse3_Spleen_MeOH_spyke_Grad10_90_10_45min_ReprosilAq_28_0120201.TXT</subfield>
    <subfield code="z">md5:f2f3aaf2a56faf4dc736f5b10b03b364</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">110592</subfield>
    <subfield code="u">https://rodare.hzdr.de/record/1261/files/18FLU14_Mouse3_Urine_spyke_Grad10_90_10_45min_ReprosilAq_27_0220201.TXT</subfield>
    <subfield code="z">md5:9d75e954b04deede74e0ca13678548f2</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:rodare.hzdr.de:1261</subfield>
    <subfield code="p">openaire_data</subfield>
    <subfield code="p">user-health</subfield>
    <subfield code="p">user-rodare</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Data Publication: Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-11-11</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">dataset</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Cannabinoid receptor type 2</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">naphtyrid-2-one</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">binding affinity</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">radiochemistry</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">fluorine-18 labeling</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">brain</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">positron emission tomography</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.14278/rodare.1261</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Moldovan, Rares-Petru</subfield>
    <subfield code="0">(orcid)0000-0003-3119-7945</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="001">1261</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-health</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-rodare</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="a">https://www.hzdr.de/publications/Publ-33389</subfield>
    <subfield code="i">isIdenticalTo</subfield>
    <subfield code="n">url</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="a">https://www.hzdr.de/publications/Publ-32557</subfield>
    <subfield code="i">isReferencedBy</subfield>
    <subfield code="n">url</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="a">10.14278/rodare.1260</subfield>
    <subfield code="i">isVersionOf</subfield>
    <subfield code="n">doi</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for neurodegenerative diseases and cancer. Aiming at a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we developed here &lt;em&gt;cis&lt;/em&gt;-[&lt;sup&gt;18&lt;/sup&gt;F]1-(4-fluorobutyl-&lt;em&gt;N&lt;/em&gt;-((1s,4s)-4-methylcyclohexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide ([&lt;sup&gt;18&lt;/sup&gt;F]&lt;strong&gt;LU14&lt;/strong&gt;) starting from the corresponding mesylate precursor. First biological evaluation revealed that [&lt;sup&gt;18&lt;/sup&gt;F]&lt;strong&gt;LU14&lt;/strong&gt; is a highly affine CB2R radioligand with &amp;gt;80% intact tracer in brain at 30 min p.i. Its further evaluation in a well-established rat model of CB2R overexpression by PET demonstrated its ability to selectively image the CB2R in the brain and its potential as tracer to further investigate diseased related CB2R changes in expression.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
</record>