NOVO - Next generation imaging for real-time dose verification enabling adaptive proton therapy

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NOVO - Next generation imaging for real-time dose verification enabling adaptive proton therapy

The NOVO project will address a fundamental issue in proton radiotherapy (PT) for cancer treatment, namely the lack of real-time dose verification (RDV) that significantly limits treatment in PT due to considerable uncertainties in the precise delivery of the prescribed dose. In the NOVO project, we will develop the first proof-of-concept of an RDV technology adaptable to any PT treatment and bring the concept to TRL 4 by also considering integration into the PT clinical workflow. The RDV technology will be pivotal for enabling the next generation of adaptive PT therapy, i.e., dose-guided real-time adaptive therapy. Verification of the dose delivered to targeted and non-targeted tissues will be the key to put the PT community on the path to true personalisation of the treatment and improvement of the quality-of-life post-treatment. As a high-risk/high-gain project, NOVO aims at a first-of-its-kind RDV technology through the unique synergy between (1) cutting-edge, inexpensive organic scintillator technology that can detect secondary radiation during treatment for non-invasive measurements, (2) novel and fast image reconstruction, artificial intelligence (AI)-accelerated models and AI-enhanced image reconstruction to allow simultaneous imaging of multiple radiation species and tissue compositional analysis (3) estimation of the physical and biological dose as well as tracking tissue oxygenation , and (4) intelligent automation of decision-making schemes for real-time dose-guided adaptive therapy, to essentially enable a new era in PT. The NOVO consortium covers the entire value chain of RDV development (technology providers, theory and modelling, technology integration and PT clinics) and optimally engages nuclear, medical, and high-energy physicists, mathematicians, computer scientists, oncologists, biologists, as well as European PT centres.

Curated by:
koeglert
Curation policy:

Entries in this community should have been generated as part of the NOVO project.

Created:
September 24, 2025
Harvesting API:
OAI-PMH Interface

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